The laboratory is presently focused on the study of the expression and regulation of two chemotactic receptors in dendritic cells. In vivo experiments have provided evidence that both receptors contribute to the localization and function of dendritic cells subsets in different organs. ChemR23 was recently identified as the receptor for chemerin, a protein rapidly activated in pathological reactions. The chemerin/ChemR23 axis was shown to play a crucial role in the regulation of myeloid and plasmacytoid dendritic cell transmigration across the endothelial barriers. Activation of ChemR23 was also associated to some autoimmune diseases, such as systemic lupus erythematosus, lichen planus and psoriasis. Conversely, CCRL2 (recently renamed AKCR5) belongs to a subset of chemokine receptors named “atypical”, because they are unable to activate the classical intracellular signal transduction pathways usually triggered by this class of receptors. CCRL2 represents a second receptor for chemerin and this laboratory has demonstrated a non-redundant role of CCRL2 in the regulation of dendritic cell migration in the lung compartment and has postulated a role for this receptor in lung hypersensitivity reactions.