Role: Head of Lab
Unit: Translational Immunology Lab
Hospital: Humanitas Clinical and Research Center, Italy

 

enrico.lugli@humanitasresearch.it

SCOPUS Author ID
6602259665

Biographical note

I obtained a PhD in Immunology in 2008 from the University Modena and Reggio Emilia, Italy, under the supervision of Prof. Andrea Cossarizza where I studied T cell immune responses and homeostasis during the course of Human Immunodeficiency Virus (HIV) infection. I then moved to the Vaccine Research Center at the National Institutes of Health in Bethesda, MD, USA to join the ImmunoTechnology Section directed by Dr. Mario Roederer. There, I studied the molecular mechanisms involved in the maintenance of long-lived T cell immunity in humans and nonhuman primates. In collaboration with Dr. Thomas Waldmann, I moved Interleukin (IL)-15, a cytokine capable of activating anti-tumor effector cells, from the preclinical level to the first-in-human phase I clinical trial in patients with solid cancers. Since 2013, I have been a Junior Investigator at the Humanitas Clinical and Research Center under the supervision of Prof. Domenico Mavilio, and since 2015 an independent principal investigator of the Laboratory of Translational Immunology.

Scientific interests

The Laboratory of Translational Immunology (LTI) is focused on understanding the biological mechanisms at the basis of memory T cell responses and homeostasis in humans and how this information can be exploited to favour immune recovery, anti-tumor and anti-viral responses in patients with cancer. The group uses high-content, 18-color flow cytometry and fluorescence-activated cell sorting (FACS), cellular assays and antigen-specific technologies to dissect the complexity of the immune system at the level of single cells. We are currently combining these approaches with molecular technologies to investigate the function of T cells at the biochemical and metabolic level. The LTI is also involved in multiple clinical trials performed at the Humanitas Cancer Center: we aim to investigate the effect of novel anti-cancer therapies on the homeostasis and function of the human T cell compartment. These projects are currently supported by a Starting Grant from the European Research Council, the Fondazione Cariplo and the Italian Ministry of Health.

If you are interested in a research position, please send a motivation letter, your CV, and the contact information (or letters of recommendation) of at least two referees to Dr. Enrico Lugli.

Selected publications

Roberto A, Castagna L, Zanon V, Bramanti S, Crocchiolo R, McLaren JE, Gandolfi S, Tentorio P, Sarina B, Timofeeva I, Santoro A, Carlo-Stella C, Bruno B, Carniti C, Corradini P, Gostick E, Ladell K, Price DA, Roederer M, Mavilio D, Lugli E.(2015): Role of naive-derived T memory stem cells in T-cell reconstitution following allogeneic transplantation, Blood, 125(18):2855-64

Conlon KC, Lugli E, Welles HC, Rosenberg SA, Fojo AT, Morris JC, Fleisher TA, Dubois SP, Perera LP, Stewart DM, Goldman CK, Bryant BR, Decker JM, Chen J, Worthy TA, Figg WD Sr, Peer CJ, Sneller MC, Lane HC, Yovandich JL, Creekmore SP, Roederer M, Waldmann TA.(2015):Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer, J Clin Oncol, 33(1):74-82

Mahnke YD, Brodie TM, Sallusto F, Roederer M, Lugli E.(2013):The who’s who of T-cell differentiation: human memory T-cell subsets, Eur J Immunol, 43(11):2797-809

Lugli E, Gattinoni L, Roberto A, Mavilio D, Price DA, Restifo NP, Roederer M.(2013):Identification, isolation and in vitro expansion of human and nonhuman primate T stem cell memory cells, Nat Protoc., 8(1):33-42

Lugli E, Dominguez MH, Gattinoni L, Chattopadhyay PK, Bolton DL, Song K, Klatt NR, Brenchley JM, Vaccari M, Gostick E, Price DA, Waldmann TA, Restifo NP, Franchini G, Roederer M.(2013): Superior T memory stem cell persistence supports long-lived T cell memory, J Clin Invest.,123(2):594-9

Galluzzi L, Lugli E.(2013):Rejuvenated T cells attack old tumors, Oncoimmunology, 2(2):e24103

Waldmann TA, Lugli E, Roederer M, Perera LP, Smedley JV, Macallister RP, Goldman CK, Bryant BR, Decker JM, Fleisher TA, Lane HC, Sneller MC, Kurlander RJ, Kleiner DE, Pletcher JM, Figg WD, Yovandich JL, Creekmore SP.(2011): Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques, Blood, 117(18):4787-95

Lugli E, Mueller YM, Lewis MG, Villinger F, Katsikis PD, Roederer M.(2011): IL-15 delays suppression and fails to promote immune reconstitution in virally suppressed chronically SIV-infected macaques, Blood, 118(9):2520-9

Gattinoni L, Lugli E, Ji Y, Pos Z, Paulos CM, Quigley MF, Almeida JR, Gostick E, Yu Z, Carpenito C, Wang E, Douek DC, Price DA, June CH, Marincola FM, Roederer M, Restifo NP., (2011):A human memory T cell subset with stem cell-like properties, Nat Med., 17(10):1290-7

Lugli E, Pinti M, Nasi M, Troiano L, Ferraresi R, Mussi C, Salvioli G, Patsekin V, Robinson JP, Durante C, Cocchi M, Cossarizza A.(2007): Subject classification obtained by cluster analysis and principal component analysis applied to flow cytometric data, Cytometry A, 71(5):334-44