Role: Head of Lab
Unit: Leukocyte Biology Lab
Hospital: Humanitas Clinical and Research Center, Italy

Role: Full Professor of General Pathology
University: University of Milan, Italy



Biographical note

Massimo Locati graduated full marks in Medicine from University of Milan (1992), was Research Fellow in the Department of Immunology and Cell Biology at Mario Negri Institute, Milan (1992-1995) and then moved in the Laboratory of Host Defenses, National Institutes of Health in Bethesda, Washington (1995-1996). He was then enrolled as Research Assistant at the University of Brescia (1998) and subsequently moved to the University of Milan (2001), were he is now Professor of Immunology and General Pathology at the Department of Medical Biotechnologies and Translational Medicine and chief of the Leukocyte Biology Lab at the Humanitas Clinical and Reseach Center.

Scientific interests

His major scientific interests is on cellular and molecular mechanisms promoting resolution of the inflammatory response. In this scientific setting, he has contributed to the characterization of biological properties of chemokines and their receptors and in particular has first revealed the decoy function and the underlying molecular mechanisms of atypical chemokine receptors. He has also first described the transcriptional profile and characterized several immune and metabolic aspects of alternatively activated macrophages. He has also described the role of transcription factors and epigenetic mechanisms, with particular relevance for microRNA, in macrophage biology. On these topics he is author of over 130 peer-reviewed publications, with a total Impact Factor 850, 12000 citations, h-index 51 and i-10 index 101.

Selected publications

Borroni ME, Cancellieri C, Vacchini A, Benureau Y, Lagane B, Bachelerie F, Arenzana-Saisdos F, Mizuno K, Mantovani A, Bonecchi R, Locati M. Arrestin-dependent regulation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6. Science Signaling 6:ra30, 2013.

Savino B, Castor MG, Caronni N, Sarukhan A, Anselmo A, Buracchi C, Benvenuti F, Pinho V, Teixeira MM, Mantovani A, Locati M, Bonecchi R. Control of Ly6Chigh monocyte traffic and immunosuppressive activities by atypical chemokine receptor D6. Blood, 119:5250-60, 2012.

Cairo G, Recalcati S, Mantovani A, Locati M. Iron trafficking and metabolism as a key component of macrophage polarization and plasticity. Trends in Immunology, 32:241-7, 2011.

Bazzoni F, Rossato M, Fabbri M, Gaudiosi D, Mirolo M, Mori L, Tamassia N, Mantovani A, Cassatella MA, Locati M. Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals. Proceedings of the National Academy of Sciences of USA 106:5282-5287, 2009.

Allegretti M, Bertini R, Bizzarri C, Beccari A, Mantovani A, Locati M. Allosteric inhibitors of chemoattractant receptors. Opportunities and pitfalls. Trends in Pharmacological Sciences 29:280-286, 2008.

Martinez de la Torre Y, Buracchi C, Borroni EM, Dupor J, Bonecchi R, Nebuloni M, Pasqualini F, Doni A, Agostinis C, Bulla R, Cook DN, Haribabu B, Meroni P, Rukavina D, Vago L, Vecchi A, Tedesco F, Lira SA, Locati M, Mantovani A. Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6. Proceedings of the National Academy of Sciences of USA 104:2319-2324, 2007.

Martinez FO, Gordon S, Locati M, Mantovani A. Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression. Journal of Immunology 177:7303-7311, 2006.

Mantovani A, Bonecchi R, Locati M. Tuning inflammation and immunity by chemokine sequestration: decoys and more. Nature Reviews in Immunology 12:907-918, 2006.

Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M. The chemokine system in diverse forms of macrophage activation and polarization. Trends in Immunology 25: 677-686, 2004.

Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends in Immunology 23:549-555, 2002..