Cecilia-Garlanda-7_ok

Role: Head of Lab
Unit: Experimental Immunopathology Lab
Hospital: Humanitas Clinical and Research Center, Italy

 

cecilia.garlanda@humanitasresearch.it

SCOPUS Author ID
6603795090

Biographical Note

She was born in 1964 and graduated in Veterinary Medicine at the Università degli Studi di Milano, in 1990. She worked at the Institute of Pharmacological Research “Mario Negri” in the Laboratory of Immunology, from 1990 to 2005, and in the Département de Biologie Moléculaire et Structurale- Unité INSERM 217-Centre d’Etudes Nucléaires de Grenoble, France, in 1994-1995. From 2005, she is the head of the Laboratory of Experimental Immunopathology at the Istituto Clinico Humanitas. She has worked on innate immunity and the regulation of inflammatory responses. She contributed to characterize a soluble mediator of the innate immune response, the long pentraxin PTX3 and characterized TIR8/SIGIRR, a negative regulator of inflammatory and immune responses, member of the family of IL-1 Receptors and Toll Like Receptors.

Scientific interests

The group is focused on the functional characterization of original molecules of the immune system, in particular on the characterization of the biological activity of the long pentraxin PTX3 in the context of innate immune responses to pathogens of fungal, bacterial or viral origin, and in the regulation of inflammatory responses in conditions of infections or tissue damage, such as wound healing and cancer. The group is also focused on TIR8, a negative regulator of inflammatory responses triggered by TLR engagement and by IL-1 family members, in particular in the context of cancer. The activities of the Laboratory mainly consist in pre-clinical studies and are finalized to the possibility of transferring the information obtained to the clinic. In particular, our efforts are aimed in transferring PTX3 as potential therapeutic molecule in opportunistic infections

Selected publications

Hirsch E, Katanaev V L, Garlanda C, Azzolino O, Pirola L, Silengo L, Sozzani S, Mantovani A, Altruda F, Wymann M P. Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science 2000; 287: 1049-1053

Garlanda C, Hirsch E, Bozza S, Salustri A, De Acetis M, Nota R, Maccagno A, Riva F, Bottazzi B, Peri G, Doni A, Vago L, Botto M, De Santis R, Carminati P, Siracusa G, Altruda F, Vecchi A, Romani L, Mantovani A. Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Nature 2002; 420: 182-186

Garlanda C, Riva F, Polentarutti N, Buracchi C, Sironi M, De Bortoli M, Muzio M, Bergottini R, Scanziani E, Vecchi A, Hirsch A, Mantovani A. Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family. Proc Natl Acad Sci USA 2004; 101: 3522-3526

Garlanda C., Bottazzi B., Bastone A., Mantovani A. Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility. Ann. Rev. Immunol. 2005, 23: 337-366.

Garlanda C, Riva F, Veliz T, Polentarutti N, Pasqualini F, Radaelli E, Sironi M, Nebuloni M, Zorini EO, Scanziani E, Mantovani A. Increased susceptibility to colitis-associated cancer of mice lacking TIR8, an inhibitory member of the interleukin-1 receptor family. Cancer Res. 2007 Jul 1;67(13):6017-21.

Garlanda C., Anders HJ, Mantovani A. TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions on inflammation and T cell polarization. Trends in Immunology 2009 Sep;30(9):439-46.

Bottazzi B, Doni A, Garlanda C, Mantovani A. An Integrated View of Humoral Innate Immunity: Pentraxins as a Paradigm. Annu Rev Immunol. 2010 Apr 23;28:157-83.

Moalli F., Doni A., Deban L., Zelante T., Zagarella S., Bottazzi B., Romani L, Mantovani A., and Garlanda C. Role of complement and Fcg receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus. Blood. 2010 Dec 9;116(24):5170-80.

Garlanda C, Dinarello CA, Mantovani A. The interleukin-1 family: back to the future. Immunity. 2013 Dec 12;39(6):1003-18.

Jaillon S, Moalli F, Ragnarsdottir B, Bonavita E, Riva F, Barbati E, Nebuloni M, Cvetko Krajinovic L, Markotic A, Valentino S, Doni A, Tartari S, Graziani G, Montanelli A, Delneste Y, Svanborg C, Garlanda C, Mantovani A. The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection. Immunity. In press.