Gianluigi Condorelli (2)_ok

Role: Director of Cardiovascular Research Area and Head of Lab
Director Department of Cardiovascular Medicine
Unit: Inflammation and Immunology in Cardiovascular Pathologies Lab
Hospital: Humanitas Clinical and Research Center, Italy

Role: Full Professor of Cardiology
University: Humanitas University, Italy


Biographical note

After receiving my MD “cum laude” at the University of Naples Federico II in 1989, I worked as a post-doctoral fellow first at the Department of Cardiology, Children’s Hospital, Harvard Medical School, Boston, MA, then at the Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, with Carlo M. Croce. I received a PhD in Cardiovascular Pathophysiology and specialized in Cardiology. I was Assistant Professor at Thomas Jefferson University, Philadelphia, PA; then Associate Research Scientist, Adjunct Associate and finally Adjunct Professor at the University of California San Diego, La Jolla, CA (2003-2012); in Italy, I was Assistant Professor, then Associate Professor of Internal Medicine at La Sapienza University, Rome; Full Professor at the University of Milan Bicocca, Scientific Director of IRCCS Multimedica Hospital, Milan; Director of the Department of Medicine and Coordinator of the Department of Biomedical Sciences of the National Research Council of Italy (2006-2012); Full Professor at University of Milan. I am now Full Professor of Cardiology at the Humanitas University, Director of the Cardiovascular Research Area at Humanitas Research Hospital and Visiting Professor and Chair of Molecular Cardiology at the University of Leicester, UK. I am member of the Editorial Board of several Scientific Journals: Journal American College Cardiology; Circulation Research, Cardiovascular Research, Journal Molecular Cellular Cardiology; Cell Death Disease.

Scientific interests

My group is interested in the molecular mechanisms of heart failure and, more broadly, of cardiovascular diseases. We study how genetics and epigenetics determine cardiovascular pathologies and, in particular, the roles of non-coding RNAs (microRNAs and, more recently, long-non coding RNAs) and histone and DNA modifications in different cardiovascular processes, in particular those affecting the myocardium. We approach the study of cardiovascular diseases with massive DNA sequencing techniques, bioinformatics, in vitro models of human diseases (cardiomyocytes obtained from induced multipotent progenitor cells derived from patients with inherited cardiomyopathies) and miniaturized, in vivo models of diseases. Our efforts are aimed also at translating knowledge from bench to bedside; in particular, we are pursuing the identification of circulating and genetic biomarkers of cardiovascular diseases, which may be used to predict disease state or response to specific drug treatments. In addition, we are pursuing the identification of molecules that ameliorate cardiac function by interfering with basic cardiomyocyte activities.

Selected publications

Papait, R., Cattaneo, P., Kunderfranco, P., Greco, C., Carullo, P., Guffanti, A., Viganò, V., Latronico, MVG, Hasenfuss, G., Chen, J., Condorelli, G. (2013): Genome-wide analysis of histone marks identifying an epigenetic signature and promoters and enhancers underlying cardiac hypertrophy, Proc. Natl. Acad. Sci. USA, 110(50):20164-9

Roncarati R, Anselmi CV, Losi MA, Papa L, Cavarretta E, Costa Martins PD, Jotti GS, Franzone A, Galastri L, Latronico MV, Imbriaco M, Esposito G, De Windt L, Betocchi S, Condorelli G. (2013): Circulating miR-29a, Among Other Upregulated microRNAs, is the Only Biomarker for Both Hypertrophy and Fibrosis in Patients with Hypertrophic Cardiomyopathy. J Am Coll Cardiol. doi:pii: S0735-1097(13)05589-7. 10.1016/j.jacc.2013.09.041

Sciarretta, S., Zhai, P., Shao, D., Maejima, Y., Robbins, J., Volpe, M., Condorelli, G., Sadoshima, J. (2012): Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome. Circulation, 125(9):1134-46

Zhang DH, Latronico MVG, Zhang JL, Contu R, Rizzi R, Catalucci D, Peterson KL, Brown JH, Chen J, Sonenberg N, Condorelli G. (2010): mTORC-1 regulates cardiac function and myocyte survival through 4E-BP-1 inhibition. J Clin Invest. 120(8):2805-16.

Elia L, Quintavalle M, Zhang J, Contu R, Cossu L, Latronico MVG, Peterson KL, Indolfi C, Catalucci D, Chen J, Courtneidge SA, Condorelli G. (2009): The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease. Cell Death and Diff. 16(12):1590-8.

Quintavalle M, Elia L, Condorelli G, Courtenidge S (2010), MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro. J Cell Biol. 189(1):13-22
Catalucci D, Zhang D-H, DeSantiago J, Picht E, Alessi DR, Dalton N, Peterson KL, Bers DM, Brown JM, Condorelli G: Akt controls cardiac inotropism through regulation of L-Type Calcium Channel assembly. J Cell Biol, 184:923-33.

Elia L, Contu R, Quitavalle M, Varrone F, Chimenti C, Russo MA, Cimino V, De Marinis L, Frustaci A, Catalucci D, Condorelli G. (2009): Reciprocal regulation of microRNA-1 and IGF-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions; Circulation, 120(23):2377-85.

Carè A, Catalucci D, Felicetti F,  Bonci  D, Ruiz-Lozano P,  Gallo P,  Segnalini P, Bang ML, Dorn GW 2nd,  Ellingsen O, Croce CM, Peschle C, Condorelli G. (2007): MicroRNA-133 controls cardiac myocyte hypertrophy. Nature Medicine, 13(5):613-8.

Condorelli G, Drusco A, Stassi G, Roncarati R, Iaccarino G, Russo MA., Gu Y, Chung C, Latronico M, Napoli C, Sadoshima J, Croce CM, Ross J Jr. (2002): Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice. Proc Natl Acad Sci USA, 99: 12333-8.

Condorelli G, Borello U, De Angelis L, Latronico M, Sirabella D, Coletta M, Galli R, Balconi G, Follenzi A, Frati G, Cusella De Angelis MG, Gioglio L, Amuchastegui S, Adorini L, Naldini L, Vescovi A, Dejana E, Cossu G. (2001): Cardiomyocytes induce endothelial cells to trans-differentiate into cardiac muscle: implications for myocardium regeneration. Proc Natl Acad Sci USA, 98, 10733-10738.