Andrea-Lania-8_ok

Role: Head of Lab and Head of Unit
Unit: Cellular and Molecular Endocrinology Lab and Endocrine Unit
Hospital: Humanitas Clinical and Research Center, Italy

Role: Assistant Professor of Endocrinology
University: Humanitas University, Italy

andrea.lania@hunimed.eu

SCOPUS Author ID
7003978830

Biographical Note

Andrea Lania was born in Milan in 1965. Dr. Lania, after the degree in Medicine and the postgraduate degree in Endocrinology at University of Milan, received the PhD degree in Endocrinological and Metabolic Sciences at the University of Milan. He was Assistant Professor at the Department of Medical Sciences at the University of Milan from 2005 to 2014. He is actually Assitant Professor at Humanitas University and the Director of the Endocrine Unit and  the Laboratory of Cellular and Molecular Endocrinology at IRCCS Istituto Clinico Humanitas. He published 106 original papers (Science Citation Index). Dr. Lania is author of more than 100 articles (h-index 25) and is member of the Editorial Board of The Journal of Clinical Endocrinology and Metabolism and the Journal of Endocrinological Investigation- He is member of the Italian Society of Endocrinology (SIE), the European Neuroendocrine Association (ENEA), The Pituitary Society, The Endocrine Society, The European Neuroendocrine Tumors Society and the Euroepan Endocrine Society (ESE)

Scientific Interests

The research activity is mainly focused on the pathogenesis of endocrine tumors (mainly pituitary and neuroendocrine tumors) and the mechanisms involved in determining the sensitivity of these tumors to medical treatment. In particular, the expression and function of the cAMP dependent pathway and its impact on cell proliferation is currently under investigation. Other areas of active research include the study of molecular basis of antiproliferative effects of drugs used in the control of both neuroendocrine tumor growth and secretion (i.e. somatostatin analogs and dopamine agonists) and the analysis of possible molecular abnormalities affecting their relative receptors

Selected publications

Vitali E, Peverelli E, Giardino E, Locatelli M, Lasio GB, Beck-Peccoz P, Spada A, Lania AG, Mantovani G. Cyclic adenosine 3′-5′-monophosphate (cAMP) exerts proliferative and anti-proliferative effects in pituitary cells of different types by activating both cAMP-dependent protein kinase A (PKA) and exchange proteins directly activated by cAMP (Epac). Mol Cell Endocrinol. 2014 Mar 5;383(1-2):193-202

Peverelli E, Busnelli M, Vitali E, Giardino E, Galés C, Lania AG, Beck-Peccoz  P, Chini B, Mantovani G, Spada A. Specific roles of G(i) protein family members revealed by dissecting SST5 coupling in human pituitary cells. J Cell Sci. 2013 Jan 15;126(Pt 2):638-44

Peverelli E, Mantovani G, Vitali E, Elli FM, Olgiati L, Ferrero S, Laws ER, Della Mina P, Villa A, Beck-Peccoz P, Spada A, Lania AG. Filamin-a is essential for dopamine d2 receptor expression and signaling in tumorous lactotrophs. J Clin Endocrinol Metab. 2012 Mar;97(3):967-77

Filopanti M, Olgiati L, Mantovani G, Corbetta S, Arosio M, Gasco V, De Marinis L, Martini C, Bogazzi F, Cannavò S, Colao A, Ferone D, Arnaldi G, Pigliaru F, Peri A, Angeletti G, Jaffrain-Rea ML, Lania AG, Spada A. Growth hormone receptor  variants and response to pegvisomant in monotherapy or in combination with somatostatin analogs in acromegalic patients: a multicenter study. J Clin Endocrinol Metab. 2012 Feb;97(2):E165-72.

Lania AG, Ferrero S, Pivonello R, Mantovani G, Peverelli E, Di Sarno A, Beck-Peccoz P, Spada A, Colao A. Evolution of an aggressive prolactinoma into a growth hormone secreting pituitary tumor coincident with GNAS gene mutation. J Clin Endocrinol Metab. 2010 Jan;95(1):13-7.

Peverelli E, Olgiati L, Locatelli M, Magni P, Fustini MF, Frank G, Mantovani G, Beck-Peccoz P, Spada A, Lania A. The dopamine-somatostatin chimeric compound BIM-23A760 exerts antiproliferative and cytotoxic effects in human non-functioning pituitary tumors by activating ERK1/2 and p38 pathways. Cancer Lett. 2010 Feb 28;288(2):170-6.

Peverelli E, Lania AG, Mantovani G, Beck-Peccoz P, Spada A. Characterization of intracellular signaling mediated by human somatostatin receptor 5: role of theDRY motif and the third intracellular loop. Endocrinology. 2009 Jul;150(7):3169-76.

Filopanti M, Barbieri AM, Angioni AR, Colao A, Gasco V, Grottoli S, Peri A,Baglioni S, Fustini MF, Pigliaru F, Monte PD, Borretta G, Ambrosi B, Jaffrain-Rea ML, Gasperi M, Brogioni S, Cannavò S, Mantovani G, Beck-Peccoz P, Lania A, Spada  A. Dopamine D2 receptor gene polymorphisms and response to cabergoline therapy in patients with prolactin-secreting pituitary adenomas. Pharmacogenomics J. 2008 Oct;8(5):357-63.

Mantovani G, Bondioni S, Lania AG, Rodolfo M, Peverelli E, Polentarutti N, Veliz Rodriguez T, Ferrero S, Bosari S, Beck-Peccoz P, Spada A. High expression of PKA regulatory subunit 1A protein is related to proliferation of human melanoma cells. Oncogene. 2008 Mar 20;27(13):1834-43.

Lania AG, Mantovani G, Ferrero S, Pellegrini C, Bondioni S, Peverelli E, Braidotti P, Locatelli M, Zavanone ML, Ferrante E, Bosari S, Beck-Peccoz P, Spada A. Proliferation of transformed somatotroph cells related to low or absent expression of protein kinase a regulatory subunit 1A protein. Cancer Res. 2004 Dec 15;64(24):9193-8